Clopidogrel Wikipedia

Clopidogrel should be used during pregnancy only if the potential benefit justifies the potential risk. This drug hasn’t been studied in children and shouldn’t be used in people younger than 18 years. Typically, your doctor will start you on a low dosage and adjust it over time to reach the dosage that’s right for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.

For comparison, the related drug, ticlodipine (Ticlid), causes TTP times more frequently than clopidogrel. The combination of clopidogrel and aspirin is better than aspirin or clopidogrel alone in preventing another heart attack but the risk of bleeding is higher. This information does not contain all possible interactions or adverse effects.

  1. Call your doctor if you have any unusual problems while taking this medication.
  2. Plavix isn’t approved to prevent heart attack or stroke in people who’ve had a coronary artery bypass graft (CABG).
  3. Here we look at how Plavix and Effient are alike and different.

If you have questions about how clopidogrel compares with other drugs, talk with your doctor or pharmacist. Its uses and side effects are similar to that of clopidogrel. For instance, clopidogrel is taken once daily, while ticagrelor’s typical dosing is twice daily.

In case of emergency/overdose

If you notice that your urine looks pink or red in color while you’re taking Plavix, call your doctor right away. They can check to see whether you’re having serious bleeding and recommend if you need medical treatment. Minor bleeding, including having occasional nosebleeds, has been reported in people using this drug.

You’ll usually take clopidogrel once a day, at the same time each day. Patients on clopidogrel should have monitoring for signs of bleeding, both visibly and via laboratory testing (hemoglobin dmt addiction what is dmt how is it abused and is it addictive and hematocrit). Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed.

Besides bleeding or bruising, most of these common side effects may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk with your doctor or pharmacist. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Do not take more or less of it or take it more often than prescribed by your doctor.

The blocked blood flow results in a lack of oxygen to your brain. This can lead to brain damage if it’s not treated right away. Plavix is approved to reduce the risk of heart attack and stroke in adults who’ve had a recent heart attack. Heart attacks occur when your heart doesn’t get enough blood flow because of blocked blood vessels or other heart problems. This results in a lack of oxygen in your heart muscle and causes damage in your heart. Plavix is used to help prevent blood clots from forming in your body.

Is Plavix an anticoagulant?

Do not stop taking clopidogrel without first talking to your doctor, even if you have signs of bleeding. Stopping the medicine could increase your risk of a heart attack or stroke. Clopidogrel bisulfate (Plavix) is an anti-platelet drug, that is, a drug that inhibits the ability of platelets to clump together as part of a blood clot. Clopidogrel prevents blood clots by irreversibly binding to the P2Y12 receptor on platelets, preventing adenosine diphosphate (ADP) from activating platelets. It belongs to a class of drugs called P2Y12 inhibitors. Other drugs in this class include ticagrelor (Brilinta) and prasugrel (Effient).

To help you remember, take it at the same time each day. Read the Medication Guide provided by your pharmacist before you start taking clopidogrel and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Several studies have shown a benefit to using these drugs together rather than taking either of the drugs alone. Stents are mesh tubes that are sometimes placed into your arteries to keep the arteries open. Stents are usually placed when someone has a blockage in their artery that is stopping blood from flowing through the artery. You likely won’t have blood pressure changes while you’re taking Plavix.

These drugs may increase the risk of bleeding/antiplatelet effect when used with clopidogrel. Plavix and Effient are both approved to prevent cardiovascular events, such as heart attack and stroke, in people who have acute coronary syndrome (ACS). With ACS, there is a lack of blood flow to your heart due to blockage.

Based on animal studies, a single dose of 1500 to 2000 mg/kg was lethal to mice and rats, and 3000 mg/kg was lethal to baboons. If any of the following medical conditions or other health factors pertain to you, be sure to talk with your doctor before taking clopidogrel. Some many at risk for alcohol-medication interactions national institutes of health nih people have genetic differences that cause variations in this enzyme. As a result, their body’s CYP2C19 enzyme doesn’t work as well as it does in others. If you have poor metabolism of this enzyme, your body isn’t able to break down clopidogrel into its active form.

Dosage and Administration

The optimal postprocedure antithrombotic strategy for TAVR is unknown, especially for patients who require concomitant anticoagulation. Various antithrombotic regimens are still under investigation. Clinicians should consider patient-specific risks for bleeding and thrombosis when making pharmacotherapy plans ACC [Otto 2017], Kalich 2018.

Unstable angina (a type of chest pain) and heart attack are two types of ACS. After up to 3 years of treatment, 9.8% of people taking Plavix had a heart attack, stroke, or other cardiovascular-related death. Of people taking aspirin, 10.6% had one of these outcomes. Clopidogrel is similar to ticlopidine (Ticlid) in chemical structure and in the way it works. Keep in mind that clopidogrel is prescribed to help prevent serious cardiovascular events, such as heart attack and stroke. Not taking the drug, including missing doses or stopping it without your doctor’s recommendation, may increase your risk of these events.

Your doctor may perform a blood test to make sure clopidogrel is right for you. You should not use clopidogrel if you have any active bleeding such as a stomach ulcer or bleeding in the brain. Studies in rats have shown that clopidogrel appears in breast milk; however, it is not known whether it also appears in human breast milk. However, not every pharmacy stocks Plavix, the brand-name form.